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HPN-01
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HPN-01图片
CAS NO:928655-63-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
HPN-01 是一种有效选择性的 IKK 抑制剂，对 IKK-α、IKK-β 和 IKK-ε 的 pIC50 6.4、7.0 和<4.8。HPN-01 比 50 多种其他激酶显示出大于50倍的选择性，包括 ALK5、CDK-2、EGFR、ErbB2、GSK3β、PLK1、Src 和 VEGFR-2。
Cas No.928655-63-4
分子式C19H16ClN3O3S
分子量401.87
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and<4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2[1].

HPN-01 effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC50=6.1, 6.4, and 5.7, respectively). HPN-01 also inhibits TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC50=5.7)[1]. HPN-01 inhibits the expression of SREBP-1and SREBP-2 in cultured primary human hepatocytes with IC50s of 1.71 μμ and 3.43 μμ, respectively. HPN-01 is being development for the treatment of nonalcoholic fatty liver disease (NAFLD)[2].

[1]. Christopher JA, et al. The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3972-7.
[2]. Ke Li, et al. Amino-aryl-benzamide compounds and methods of use thereof.WO2018204775A1.