| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | O=C([C@H]1NC(CC1)=O)N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O.OC(C(F)(F)F)=O |
| 分子式 | C51H68N14O11S·XCF3COOH |
| 分子量 | 1085.2 |
| 溶解度 | Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Litorin is a peptide originally isolated fromL. aureathat has diverse biological activities.1,2,3,4It is an agonist of the gastrin-releasing peptide receptor (GRPR) and the neuromedin B (NMB) receptor in BALB/c 3T3 fibroblasts expressing the human receptors (EC50s = 0.44 and 0.03 nM, respectively) and binds to frog bombesin receptor subtype 4 (BB4) in CHO-K1 cells (Ki= 1.2 nM).2,3Litorin (10-100 ng/kg) induces contractions of isolated guinea pig gallbladder.4It decreases food intake in rats when administered at doses ranging from 4 to 128 µg/kg.1 1.Kulkosky, P.J., and Gibbs, J.Litorin suppresses food intake in ratsLife Sci.31(7)685-692(1982) 2.Uehara, H., GonzÁlez, N., Sancho, V., et al.Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differsPeptides32(8)1685-1699(2011) 3.Katsuno, T., Pradhan, T.K., Ryan, R.R., et al.Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R)Biochemistry38(22)7307-7320(1999) 4.Endean, R., Erspamer, V., Falconieri Erspamer, G., et al.Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aureaBr. J. Pharmacol.55(2)213-219(1975) |
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