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7β-hydroxy Cholesterol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7β-hydroxy Cholesterol图片
CAS NO:566-27-8
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
7β-羟基胆固醇是一种通过胆固醇氧化得到的氧固醇。
Cas No.566-27-8
别名胆甾-5-烯-3,7二醇,7β-Hydroxycholesterol
化学名(3β,7β)-cholest-5-ene-3,7-diol
Canonical SMILESO[C@H](C1)CC[C@@]2(C)C1=C[C@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C
分子式C27H46O2
分子量402.7
溶解度20mg/mL in ethanol, 0.1mg/mL in DMSO, 2mg/mL in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.[1] It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.[2]

Reference:
[1]. Lizard, G., Monier, S., Cordelet, C., et al. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler. Thromb. Vasc. Biol. 19(5), 1190-1200 (1999).
[2]. Ziedén, B., Kaminskas, A., Kristenson, M., et al. Increased plasma 7 β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. Artioscler.Thromb.Vasc.Biol. 19(4), 967-971 (1999).