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FAP-2286
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FAP-2286图片
CAS NO:2581741-18-4
包装:1mg
市场价:6480元

产品介绍
FAP-2286,一种与放射性核素螯合剂 DOTA 偶联的 FAP 结合肽大环化合物。FAP-2286 对人 FAP 蛋白具有强亲和力,Kd 为 1.1 nM。FAP-2286 是一种肿瘤显像剂,是研究正电子发射断层扫描 (PET) 的有用工具。FAP-2286 具有抗肿瘤活性。
Cas No.2581741-18-4
分子式C67H99N13O18S3
分子量1470.77
溶解度Water : ≥ 100 mg/mL (67.99 mM)
储存条件Store at -20°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FAP-2286, a fibroblast activation protein (FAP)-binding peptidic macrocycle coupled to the radionuclide chelator DOTA. FAP-2286 has potent affinity to human FAP protein with a Kd of 1.1 nM. FAP-2286, a tumor imaging agent, is a useful tool for the research of positron emission tomography (PET). FAP-2286 has antitumor activity[1][2].

[1]. Dirk Zboralski, et al. Comparative Biodistribution and Radiotherapeutic Efficacy of the Fibroblast Activation Protein (FAP)-Targeting Agents FAP-2286 and FAPI-46.
[2]. Richard P Baum, et al. Feasibility, Biodistribution, and Preliminary Dosimetry in Peptide-Targeted Radionuclide Therapy of Diverse Adenocarcinomas Using 177 Lu-FAP-2286: First-in-Humans Results. J Nucl Med. 2022 Mar;63(3):415-423.