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Ponicidin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ponicidin图片
CAS NO:52617-37-5
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Ponicidin(RubescensineB)是源于冬凌草的二萜,具有免疫调节、抗炎、抗病毒和抗癌作用。Ponicidin(RubescensineB)可诱导胃癌细胞凋亡(apoptosis),降低JAK2和STAT3的磷酸化水平,单对其蛋白水平无作用。
Cas No.52617-37-5
别名冬凌草乙素,Rubescensine B
Canonical SMILESO[C@]12[C@]3(C4=O)[C@]5([H])C6([C@](O[C@@]3([H])[C@](CC5)([H])C4=C)([H])O2)[C@](C(C)(CC[C@@H]6O)C)([H])[C@@H]1O
分子式C20H26O6
分子量362.42
溶解度DMSO: 250 mg/mL (689.81 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].

[1]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89.