| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Cell lines | RAW264.7 macrophages |
Preparation Method | The cells were treated with various concentrations of taraxerol or LPS plus taraxerol for 24 h. Then cells were incubated with 5 mg/ml of MTT working solution for 4 h at 37℃. After being treated with 100 μl of DMSO to dissolve the crystals, the cells were detected under an ELx800 Universal Microplate Reader to measure the absorbance at 570 nm. |
Reaction Conditions | 0、10、20、40 μM Taraxerol for 1h |
Applications | Taraxerol downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation. |
Animal models | Wistar rats (♂, 150 ± 20 g) |
Preparation Method | groups were treated with taraxerol at the doses of 5 and 10 mg/kg, i.p., respectively. |
Dosage form | 5 and 10 mg/kg Taraxerol for 0-4h |
Applications | Taraxerol treatment significantly attenuated carrageenan induced paw edema 2 h onward. The anti-inflammatory effect of taraxerol was sustained up to 4 h. |
| 产品描述 | Taraxerol has anti-inflammatory and anticancer effects. Taraxerol attenuates acute inflammation by inhibiting NF-κB signaling[5,6]. Taraxerol downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation[3]. Taraxerol enhanced ROS levels and attenuated the MMP (Δψm) in HeLa cells. Taraxerol induced apoptosis mainly via the mitochondrial pathway including the release of cytochrome c to the cytosol and activation of caspases 9 and 3, and anti-poly (ADPribose) polymerase (PARP). Taraxerol could induce the down-regulation of the anti-apoptotic protein Bcl-2 and up-regulation of pro-apoptotic protein Bax. It suppressed the PI3K/ Akt signaling pathway[1]. Taraxerol treatment significantly attenuated carrageenan induced paw edema 2 h onward. The anti-inflammatory effect of taraxerol was sustained up to 4 h[2]. Taraxerol (20mg/kg, p.o.) treatment stimulated glucose metabolism in skeletal muscle, regulated blood glycaemic status and lipid profile in the sera, reduced the secretion of pro-inflammatory cytokines, and restored the renal physiology in T2D rats[4]. AChE activity inhibition in animals and indicate that Taraxerol has anti-amnesic activity that may hold significant therapeutic value in alleviating certain memory impairments observed in AD[7]. References: |
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