HC Toxin 是一种环状四肽，是一种有效的 HDAC 抑制剂，IC50 为 30 nM。 HC Toxin 可诱导肿瘤细胞凋亡并具有抗癌作用。
| Cas No. | 83209-65-8 |
| 别名 | 玉米圆斑病菌毒素 |
| Canonical SMILES | [H][C@@]12C(N([H])[C@@H](C)C(N([H])[C@H](C)C(N([H])[C@](CCCCCC([C@@H]3CO3)=O)([H])C(N1CCC2)=O)=O)=O)=O |
| 分子式 | C21H32N4O6 |
| 分子量 | 436.5 |
| 溶解度 | DMSO: 10 mg/ml,Methanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. |
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