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GSK-J5(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK-J5(hydrochloride)图片
CAS NO:1797983-32-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
GSK-J5(盐酸盐)是 GSK J2 的一种可渗透细胞的酯衍生物,无活性。 GSK-J5(盐酸盐)也是 GSK-J4 的异构体,通常用作阴性基团。
Cas No.1797983-32-4
Canonical SMILESO=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CN=C4)=N1.Cl
分子式C24H27N5O2•HCl
分子量454
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2); (1:7): 0.1 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 >100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.