GSK-J5（盐酸盐）是 GSK J2 的一种可渗透细胞的酯衍生物，无活性。 GSK-J5（盐酸盐）也是 GSK-J4 的异构体，通常用作阴性基团。
| Cas No. | 1797983-32-4 |
| Canonical SMILES | O=C(OCC)CCNC1=CC(N2CCC(C=CC=C3)=C3CC2)=NC(C4=CC=CN=C4)=N1.Cl |
| 分子式 | C24H27N5O2•HCl |
| 分子量 | 454 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2); (1:7): 0.1 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1 , an inhibitor of JMJD3. GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 >100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. |
m.cnreagent.com