CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM.
| Cas No. | 193551-00-7 |
| Canonical SMILES | ONC(=O)CCCCCNC(=O)c1ccc(cc1)N(C)C |
| 分子式 | C15H23N3O3 |
| 分子量 | 293.4 |
| 溶解度 | DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:5): 300 µ g/ml,DMSO: 14 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 µM. Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA. However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC. |
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