Amifostine (hydrate) (WR2721 trihydrate) 是一种广谱细胞保护剂和辐射保护剂。氨磷汀（水合物）选择性地保护正常组织免受放射和化学疗法造成的损害。 Amifostine (hydrate) 是有效的缺氧诱导因子-α1 (HIF-α1) 和 p53 诱导剂。氨磷汀（水合物）通过清除氧衍生的自由基来保护细胞免受损伤。氨磷汀（水合物）可降低肾毒性并具有抗血管生成作用。
| Cas No. | 112901-68-5 |
| 别名 | 氨磷汀三水合物,WR2721 trihydrate |
| Canonical SMILES | NCCCNCCSP(O)(O)=O.O.O.O |
| 分子式 | C5H15N2O3PS•3H2O |
| 分子量 | 268.3 |
| 溶解度 | PBS (pH 7.2): 5 mg/ml |
| 储存条件 | Store at 2-8℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Amifostine is a prodrug that through dephosphorylation by alkaline phosphatase is converted to an active thiol, WR 1065 that has free radical scavenging, DNA protective, and hypoxia inducing activities. Because of the differential expression of alkaline phosphatase in normal versus neoplastic tissues, the cytoprotection conferred by amifostine is selective, enabling as much as 100-fold greater accumulation of WR 1065 in normal tissues than in tumor cells. Amifostine has been used to reduce toxicity in normal tissues exposed to radiation or chemotherapeutic agents. In mouse fibroblasts and various cancer cells, amifostine (IC50 = 4 mM) has been shown to activate p53 protein, to induce the expression of the cyclin-dependent kinase inhibitor p21, and to arrest cells at the G1/S transition through a p53-dependent mechanism. |
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