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TSI-01
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
TSI-01图片
CAS NO:704878-75-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.704878-75-1
Canonical SMILESO=C(C(Cl)=C1Cl)N(C2=CC=C(C(OC(C)C)=O)C=C2)C1=O
分子式C14H11Cl2NO4
分子量328.2
溶解度DMF: 50 mg/ml,DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 &#181M for human LPCAT2 and LPCAT1, respectively). At 60 &#181M it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.