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HDAC3 Inhibitor
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HDAC3 Inhibitor图片
CAS NO:2044701-99-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
HDAC3 Inhibitor (compound 5) 是一种有效的选择性 HDAC3 抑制剂，IC50 为 5.96 nM。
Cas No.2044701-99-5
Canonical SMILESO=C(NCC1=CC=C(C(NNCCC)=O)C=C1)/C=C/C2=CC=CC=C2
分子式C20H23N3O2
分子量337.4
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM). It is selective for HDAC3 over HDAC1 and HDAC2 (IC50s = 0.95, 11.81, and 95.45 nM, respectively, using recombinant HDACs). In addition, it is selective for acute myeloid, monocytic, and lymphoblastic leukemia cell lines (EC50s = 36.37, 76.64, and 151.7 nM, respectively) over chronic myeloid, acute promyelocytic, and acute lymphoblastic cells (EC50s = 2,160, >10,000, and >10,000 nM, respectively).