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Bobcat339 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bobcat339 hydrochloride图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Bobcat339hydrochloride是基于胞嘧啶的TET酶抑制剂,对TET1和TET2的IC50值分别33μM和73μM。它可用于表观遗传学领域研究,并且可作为靶向DNA甲基化和基因转录新疗法的起点。
Canonical SMILESNC1=NC(N(C2=CC=CC(C3=CC=CC=C3)=C2)C=C1Cl)=O.Cl
分子式C16H13Cl2N3O
分子量334.2
溶解度DMSO : 130 mg/mL (388.99 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bobcat339 hydrochloride is a cytosine-based TET enzyme inhibitor with IC50 of 33 μM (TET1) and 73 μM (TET2). It is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription. IC50: 33 μM (TET1), 73 μM (TET1)[1]

[1]. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.