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Tauroursodeoxycholic Acid-d4 MaxSpec® Standard
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tauroursodeoxycholic Acid-d4 MaxSpec® Standard图片
CAS NO:2410279-94-4
包装:100µg
市场价:3100元

产品介绍
Tauroursodeoxycholic Acid-d4 MaxSpec®；标准品是氘标记的牛磺熊去氧胆酸盐。 Tauroursodeoxycholate (Tauroursodeoxycholic acid) 是一种内质网 (ER) 应激抑制剂。 Tauroursodeoxycholate 显着降低凋亡分子的表达，例如 caspase-3 和 caspase-12。 Tauroursodeoxycholate 也抑制 ERK。
Cas No.2410279-94-4
别名Tauroursodeoxycholic acid-d4; TUDCA-d4; UR 906-d4
Canonical SMILESC[C@H](CCC(NCCS(O)(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式C26H41D4NO6S
分子量503.7
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tauroursodeoxycholic acid-d4(TUDCA-d4) is intended for use as an internal standard for the quantification of tauroursodeoxycholic acid by GC- or LC-MS. TUDCA is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .1,2TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.2It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington's disease, ischemic brain injury, and retinal disorders.3,2

TUDCA-d4MaxSpec® Standard is a quantitative grade standard of TUDCA-d4that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This TUDCA-d4MaxSpec® standard is guaranteed to meet identity, purity, and stability specifications and is provided with a batch-specific Certificate of Analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product.Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

1.Beuers, U.Effects of bile acids on hepatocellular signaling and secretionYale J. Biol. Med.70(4)341-346(1997) 2.Boatright, J.H., Nickerson, J.M., Moring, A.G., et al.Bile acids in treatment of ocular diseaseJ. Ocul. Biol. Dis. Infor.2(3)149-159(2009) 3.Vang, S., Longley, K., Steer, C.J., et al.The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseasesGlob. Adv. Health Med.3(3)58-69(2014)