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Pipemidic Acid(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pipemidic Acid(hydrate)图片
CAS NO:72571-82-5
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议
25g电议

产品介绍
An antibiotic
Cas No.72571-82-5
别名吡哌酸三水合物
Canonical SMILESO=C(C1=CN(CC)C2=NC(N3CCNCC3)=NC=C2C1=O)O.O.O.O
分子式C14H17N5O3•3H2O
分子量357.4
溶解度DMF: 0.50 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pipemidic acid is an antibiotic and derivative of piromidic acid .1It is active against clinical isolates ofE. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, andV. parahaemolyticus(MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates ofE. coli, P. mirabilis, Klebsiella, andShigella(MICs = 1.56-6.25 µg/ml). Pipemidic acid is protective against systemicS. aureus, E. coli, K. pneumoniae, andP. aeruginosainfections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively).2It is also protective againstP. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well asE. coli, K. pneumoniae, andP. aeruginosaurinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice.

1.Shimizu, Y., Takase, Y., Nakamura, S., et al.Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: In vitro propertiesAntimicrob. Agents Chemother.8(2)132-138(1975) 2.Shimizu, M., Takdase, Y., Nakamura, S., et al.Pipemidic acid: Its activities against various experimental infectionsAntimicrob. Agents Chemother.9(4)569-574(1976)