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Ebselen
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ebselen图片
CAS NO:60940-34-3
包装与价格：
包装价格(元)
50mg电议
100mg电议

产品介绍
Ebselen (SPI-1005) 是一种谷胱甘肽过氧化物酶模拟物，是一种有效的电压依赖性钙通道 (VDCC) 阻滞剂。
Cas No.60940-34-3
别名依布硒; SPI-1005; PZ-51; CCG-39161
化学名2-phenylbenzo[d][1,2]selenazol-3(2H)-one
Canonical SMILESO=C1C2=CC=CC=C2[Se]N1C3=CC=CC=C3
分子式C13H9NOSe
分子量274.18
溶解度≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ebselen (SPI-1005) is an inhibitor of HIV-1 capsid CTD dimerization[1]. Ebselen can permeate the blood-brain barrier and inhibit inositol monophosphatase (IMPase). Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties[2]. Ebselen inhibits QSOX1 enzymatic activity and has anticancer activity [3].

Ebselen (SPI-1005) inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process[1]. Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain[2].

References:
[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.
[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.
[3]. Hanavan PD, et al. Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget. 2015 Jul 30;6(21):18418-28.