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JF-NP-26
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JF-NP-26图片
包装:5mg
市场价:3896元

产品介绍
JF-NP-26 是 raseglurant 的无活性光笼衍生物,是第一个笼状 mGlu5 受体负变构调节剂。
Canonical SMILESCC1=CC(C)=C(NC(OCC2=CC(OC3=C2C=CC(N(CC)CC)=C3)=O)=O)C(C#CC4=CC=CC(F)=C4)=N1
分子式C30H28FN3O4
分子量513.56
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Caged Raseglurant . Releases raseglurant upon exposure to 405 nm (violet) light. Inhibits the effects of Quisqualate in cultured neurons when exposed to 405 nm light. Exhibits analgesic activity in pain models in vivo on photoactivation. Quantum yield = 0.18.

Font et al (2017) Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. eLIFE 6 e23545 PMID:28395733