您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > prostate apoptosis response protein PAR-4(2-7)[Homo sapiens]
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
prostate apoptosis response protein PAR-4(2-7)[Homo sapiens]
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
prostate apoptosis response protein PAR-4(2-7)[Homo sapiens]图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

Transcriptional repressor

别名H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH
Canonical SMILESCC(C(NC(C(O)C)C(NCC(NCC(NC(CC1=CC=C(O)C=C1)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)N
分子式C26H41N9O9
分子量623.66
溶解度≥ 62.3mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens], (C26H41N9O9), a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66. Prostate apoptosis response-4 (Par-4), is a human gene coding for a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells.The tumor suppressor PAR-4 represses and activates transcription. The protein encoded by this gene is a PAR-4-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of PAR-4. This protein is specifically upregulated during apoptosis of prostate cells1.The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance2.

References:
1. Johnstone, R W; See R H, Sells S F, Wang J, Muthukkumar S, Englert C, Haber D A, Licht J D, Sugrue S P, Roberts T, Rangnekar V M, Shi Y (Dec. 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6945-56.
2. Zhao Y, Burikhanov R, Qiu S, Lele SM, JenningsCD, Bondada S, Spear B, Rangnekar VM (2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Res. 67 (19): 9276-85.