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Compstatin(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Compstatin(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A peptide inhibitor of complement activation
Canonical SMILESO=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC1=O)=O)CC2=CN=CN2)=O)CC3=CN=CN3)=O)CCCNC(N)=N)=O)C(N[C@H]([C@@H](C)O)C(N)=O)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)C(C)C)=O)C(C)C)=O)CCC(N)=O)=O)CC(O)=O)N[C@H]1CC4=CNC5=CC=CC=C45.OC(C(F)(F)F)=O
分子式C66H99N23O17S2·XCF3COOH
分子量1550.8
溶解度DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: slightly soluble,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Compstatin is a cyclic peptide inhibitor of complement activation (IC50s = 63 and 12 µM for the classical and alternative pathways, respectively).1,2It binds to complement component 3 (C3) and inhibits convertase-mediated cleavage of C3 to the complement activation products C3a and C3b.3Compstatin (70 µM) inhibits the generation of C3a, activation of polymorphonuclear leukocytes (PMNs), and the binding of PMNs to the polymer surface in an isolated human whole blood model of extracorporeal circulation.4In vivo, compstatin (21 mg/kg) inhibits the generation of C3b, C3c, and iC3b in a baboon model of heparin- and protamine-induced complement activation.5

1.Sahu, A., Kay, B.K., and Lambris, J.D.Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide libraryJ. Immunol.157(2)884-891(1996) 2.Huang, Y.Evolution of compstatin family as therapeutic complement inhibitorsExpert Opin. Drug Discov.13(5)435-444(2018) 3.Ricklin, D., and Lambris, J.D.Compstatin: A complement inhibitor on its way to clinical applicationAdv. Exp. Med. Biol.632273-292(2008) 4.Nilsson, B., Larsson, R., Hong, J., et al.Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulationBlood92(5)1661-1667(1998) 5.Soulika, A.M., Khan, M.M., Hattori, T., et al.Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboonsClin. Immunol.96(3)212-221(2000)