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Fmoc-Ala-Glu-Asn-Lys-NH2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fmoc-Ala-Glu-Asn-Lys-NH2图片
CAS NO:220701-06-4
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
Fmoc-Ala-Glu-Asn-Lys-NH2是一种选择性天冬酰胺内肽酶AEP抑制肽，可抑制淀粉样前体蛋白APP裂解。AEP是一种pH值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导APP蛋白水解过程。
Cas No.220701-06-4
分子式C33H43N7O9
分子量681.74
溶解度DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)
储存条件-20℃, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1].

Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.