| CAS NO: | 3650-73-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 3650-73-5 |
| 别名 | 高肌肽; L-Homocarnosine; γ-Aminobutyryl-L-histidine |
| Canonical SMILES | OC([C@H](CC1=CN=CN1)NC(CCCN)=O)=O |
| 分子式 | C10H16N4O3 |
| 分子量 | 240.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Homocarnosine is a dipeptide composed of GABA and L-histidine that has been found in cerebrospinal fluid and the brain.1It inhibits lipid peroxidation induced by AAPH when used at a concentration of 10 mM.2Homocarnosine (1 mM) decreases lactate dehydrogenase (LDH) and prostaglandin E2release from PC12 cells in anin vitromodel of ischemia induced by oxygen-glucose deprivation.3It reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).4Homocarnosine (5 mg/animal) reduces mortality in a mouse model of subcutaneousS. aureusinfection.5 1.Crush, K.G.Carnosine and related substances in animal tissuesComp. Biochem. Physiol.34(1)3-30(1970) 2.Kohen, R., Yamamoto, Y., Cundy, K.C., et al.Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brainProc. Natl. Acad. Sci. USA85(9)3175-3179(1988) 3.Tabakman, R., Lazarovici, P., and Kohen, R.Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemiaJ. Neurosci. Res.68(4)463-469(2002) 4.Huang, J., Wang, T., Yu, D., et al.L-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of nod-like receptor protein 3 inflammasomeInt. J. Biol. Macromol.118(Pt A)357-364(2018) 5.Mukkada, A.J., Nutini, L.G., and Cook, E.S.Prophylactic effects of γ-aminobutyrylhistidine (homocarnosine) on experimental staphylococcal infections in miceAppl. Microbiol.18(4)641-645(1969) |
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