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Carbamazepine-d10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carbamazepine-d10图片
CAS NO:132183-78-9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
卡马西平-D10 (CBZ-d10) 是氘标记的卡马西平。
Cas No.132183-78-9
别名5H-二苯并[B,F]氮杂卓-5-甲酰胺-D10,CBZ-d10; NSC 169864-d10
Canonical SMILESO=C(N1C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C31)N
分子式C15H2D10N2O
分子量246.3
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Carbamazepine-d10is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant.1,2It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively). Dietary administration of carbamazepine (0.75% w/w) reduces immobility time in the tail suspension test.3It also attenuates clonidine-induced aggressive behavior in mice.4Formulations containing carbamazepine have been used in the treatment of epilepsy and bipolar disorder.

1.?uszczki, J.J., Marzeda, P., Gut-Lepiech, A., et al.New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure modelPharmacol. Rep.71(2)299-305(2019) 2.Borowicz-Reutt, K.K., Banach, M., and Rudkowska, M.Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in micePharmacol. Rep.72(1)80-86(2020) 3.Kara, N.Z., Karpel, O., Toker, L., et al.Chronic oral carbamazepine treatment elicits mood-stabilising effects in miceActa Neuropsychiatr.26(1)29-34(2014) 4.Fujiwara, Y., Takeda, T., Kazahaya, Y., et al.Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in miceInt. J. Neurosci.42(1-2)77-84(1988)