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INNO-8875
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
INNO-8875图片
CAS NO:871108-05-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
INNO-8875 (INO-8875) 是一种腺苷模拟物,是一种高度选择性的腺苷 A1 受体激动剂。
Cas No.871108-05-3
别名INO-8875
Canonical SMILESO[C@H]1[C@](O[C@@H]([C@H]1O)CO[N+]([O-])=O)([H])N2C3=NC=NC(NC4CCCC4)=C3N=C2
分子式C15H20N6O6
分子量380.4
溶解度DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

INNO-8875 is an adenosine A1receptor agonist.1,2It binds to adenosine A1receptors (Ki= 0.97 nM) and is greater than 10,000-fold selective for adenosine A1over A2receptors. Topical application of INNO-8875 (25 µg/eye) reduces intraocular pressure in a rabbit model of ocular hypertension.2INNO-8875 (1-50 µg/kg) decreases atrial refractoriness and heart rate, as well as slows atrioventricular nodal conduction, in anesthetized rats.1

1.Mor, M., Shalev, A., Dror, S., et al.INO-8875, a highly selective A1 adenosine receptor agonist: Evaluation of chronotropic, dromotropic, and hemodynamic effects in ratsJ. Pharmacol. Exp. Ther.344(1)59-67(2012) 2.Kim, N., Crosson, C., Supuran, C., et al.INO-8875, an adenosine A1 agonist, in development for open-angle glaucoma reduces IOP in three rabbit modelsInvert. Ophthalmol. Vis. Sci.50(13)4061(2009)