CAS NO: | 1216984-85-8 |
包装: | 5mg |
市场价: | 10569元 |
Cas No. | 1216984-85-8 |
别名 | 利扎曲坦苯甲酸盐 d6 (苯甲酸盐) |
Canonical SMILES | OC(C1=CC=CC=C1)=O.[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C2=C3)=CNC2=CC=C3CN4C=NC=N4 |
分子式 | C15H13D6N5•C7H6O2 |
分子量 | 397.5 |
溶解度 | DMSO: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Rizatriptan-d6is intended for use as an internal standard for the quantification of rizatriptan by GC- or LC-MS. Rizatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1Band 5-HT1D(Kis = 4.3 and 10.1 nM, respectively).1It is selective for 5-HT1Band 5-HT1Dreceptors over 5-HT1Areceptors (Ki= 140 nM). Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries (EC50= 90 nM).2In vivo, rizatriptan (50 and 75 mg/kg) reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in aCacna1amutant transgenic mouse model of migraine.3Formulations containing rizatriptan have been used in the treatment of migraine. 1.Xu, Y.-C., Schaus, J.M., Walker, C., et al.N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonistJ. Med. Chem.42(3)526-531(1999) 2.Longmore, J., Razzaque, Z., Shaw, D., et al.Comparison of the vasoconstrictor effects of rizatriptan and sumatriptan in human isolated cranial arteries: Immunohistological demonstration of the involvement of 5-HT1B-receptorsBr. J. Clin. Pharmacol.46(6)577-582(1998) 3.Chanda, M.L., Tuttle, A.H., Baran, I., et al.Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant micePain154(8)1254-1262(2013) |