| CAS NO: | 57-64-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 57-64-7 |
| 别名 | 水杨酸毒扁豆碱; Eserine salicylate |
| Canonical SMILES | CNC(OC1=CC([C@@](CCN2C)(C)[C@@]2([H])N3C)=C3C=C1)=O.OC(C4=C(O)C=CC=C4)=O |
| 分子式 | C15H21N3O2•C7H6O3 |
| 分子量 | 413.5 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | (-)-Physostigmine is an alkaloid that has been found in Calabar beans and a cholinergic agent.1,2It inhibits acetylcholinesterase (AChE; IC50= 0.67 nM).2(-)-Physostigmine (10 µM) inhibits ChE and increases vagal stimulation-induced ACh output in isolated chicken heart.3In vivo, (-)-physostigmine (200 and 400 µg/kg) induces decentralized lower eyelid contractions and increases blood pressure in anesthetized rats.4 1.Proudfoot, A.The early toxicology of physostigmine: a tale of beans, great men and egosToxicol. Rev.25(2)99-138(2006) 2.Ogura, H., Kosasa, T., Kuriya, Y., et al.Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitroMethods Find. Exp. Clin. Pharmacol.22(8)609-613(2000) 3.Dieterich, H.A., Kaffel, H., Kilbinger, H., et al.The effects of physostigmine on cholinesterase activity, storage and release of acetylcholine in the isolated chicken heartJ. Pharmacol. Exp. Ther.199(1)236-246(1976) 4.SzeberÉnyi, J., Varga, A., PongrÁcz, M.F., et al.Centrally mediated contraction of the lower eyelid elicited by anticholinesterases in anaesthetized ratsJ. Pharm. Pharmacol.24(1)85-86(1972) |
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