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GSK1702934A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GSK1702934A图片
CAS NO:924377-85-5
包装:5mg
市场价:810元

产品介绍
GSK1702934A是一种选择性的 TRPC3 激动剂。GSK1702934A 通过激活 TRPC3 调节心脏收缩力和心律失常。
Cas No.924377-85-5
Canonical SMILESO=C1NC2=CC=CC=C2N1C3CCN(C(C4=CC(CCCCC5)=C5S4)=O)CC3
分子式C22H25N3O2S
分子量395.52
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2].

[1]. de la Cruz GG, et al. Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core. Synlett. 2017 Apr;28(6):695-700. [2]. Doleschal B, et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015 Apr 1;106(1):163-73.