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Sigma-1 receptor antagonist 3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Sigma-1 receptor antagonist 3图片
CAS NO:1639220-17-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Sigma-1 receptor antagonist 3 (化合物 135) 是有效的，选择性 Sigma-1 (σ1) 受体拮抗剂，Ki 为 1.14 nM。Sigma-1 receptor antagonist 3 抑制 hERG，IC50 为 1.54μM。Sigma-1 receptor antagonist 3 用于治疗神经性疼痛。
Cas No.1639220-17-9
Canonical SMILESCC1=NC(C2=CC=C(F)C=C2)=NC(OCCCN3CCCCC3)=C1Cl
分子式C19H23ClFN3O
分子量363.86
溶解度DMSO: 12.5 mg/mL (34.35 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1].

[1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.