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Lavendustin B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lavendustin B图片
CAS NO:125697-91-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Lavendustin B 是一种 HIV-1 整合酶与 LEDGF/p75 相互作用的抑制剂，IC50 为 94.07 μM。 Lavendustin B 是一种 ATP 竞争性 GLUT1 抑制剂，Ki 为 15 μM。 Lavendustin B 也是酪氨酸激酶的弱抑制剂。
Cas No.125697-91-8
别名薰草菌素B
Canonical SMILESOC1=CC=CC=C1CN(C2=CC(C(O)=O)=C(O)C=C2)CC3=CC=CC=C3O
分子式C21H19NO5
分子量365.4
溶解度DMF: 10 mg/mL,DMSO: 10 mg/mL,Ethanol: 10 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lavendustin B is a competitive inhibitor of glucose transporter 1 (Glut1; Ki = 15 μM).1 It is also an inhibitor of the interaction between HIV-1 integrase and LEDGF/p75 (IC50 = 94.07 μM).2 Lavendustin B is a weak inhibitor of tyrosine kinases (IC50 = 0.49 μg/ml) and has been used as a negative control for the protein tyrosine kinase inhibitor lavendustin A .3,4,5

References
1. Vera, J.C., Reyes, A.M., VelÁsquez, F.V., et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry 40(3), 777-790 (2001).
2. De Luca, L., Morreale, F., Christ, F., et al. New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: Virtual screening and activity assays. Eur. J. Med. Chem. 68, 405-411 (2013).
3. Onoda, T., Iinuma, H., Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J. Nat. Prod. 52(6), 1252-1257 (1989).
4. Hu, D.E., and Fan, T.-P.D. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br. J. Pharmacol. 114(2), 262-268 (1995).
5. Alioua, A., Mahajan, A., Nishimaru, K., et al. Coupling of c-Src to large conductance voltage- and Ca2+-activated K+ channels as a new mechanism of agonist-induced vasoconstriction. Proc. Natl. Acad. Sci. USA 99(22), 14560-14565 (2002).