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Isoflurane
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Isoflurane图片
CAS NO:26675-46-7
包装与价格:
包装价格(元)
1g电议
5g电议

产品介绍
A halogenated ether with anesthetic properties
Cas No.26675-46-7
别名异氟醚
Canonical SMILESFC(OC(Cl)C(F)(F)F)F
分子式C3H2ClF5O
分子量184.5
溶解度DMF: miscible,DMSO: miscible,Ethanol: miscible,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
储存条件Store at 2-8℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Isoflurane is a halogenated ether with anesthetic properties.1 While the mechanism of isoflurane anesthesia is not fully understood, mice resistant to isoflurane anesthesia have an 86% decrease in gene expression for the GABAA receptor subunit β1 compared with isoflurane-sensitive mice, indicating that the GABAA receptor may be required for its anesthetic effect. In mice, isoflurane (1.5% for 4 hours) impairs spatial recognition memory in the spontaneous alternation test and Y-maze and increases levels of phosphorylated Jnk1/2 for at least 24 hours.2 Formulations containing isoflurane have been used as anesthetics.

References
1. Wang, X., Song, Z.G., Huang, D.X., et al. A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice. Genet. Mol. Res. 15(2), gmr.15027340 (2016).
2. Jiang, S., Miao, B., and Chen, Y. Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice. Neuroreport. 28(7), 386-390 (2017).