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SN 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SN 2图片
CAS NO:823218-99-1
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8±0.13 μM。
Cas No.823218-99-1
Canonical SMILESCC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4
分子式C17H21NO
分子量255.35
溶解度DMSO: 100 mg/mL (391.62 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at -80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at -80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].

[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.