| CAS NO: | 53608-86-9 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| Cas No. | 53608-86-9 |
| 别名 | 去甲脱氧氯酸,23-NDCA, 23-Nordeoxycholic Acid |
| 化学名 | (3α,5β,12α)- 3,12- dihydroxy-24- norcholan -23- oic acid |
| Canonical SMILES | C[C@H](CC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C |
| 分子式 | C23H38O4 |
| 分子量 | 378.6 |
| 溶解度 | DMF: 15mg/mL,DMF:PBS (pH 7.2) (1:4): 0.2mg/mL,DMSO: 10mg/mL,Ethanol: 10mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nordeoxycholic acid is a metabolite of the bile acid norcholic acid and a 23-carbon derivative of deoxycholic acid .1Levels of nordeoxycholic acid are decreased in the liver of rats in a high-fat diet model of non-alcoholic fatty liver disease (NAFLD) and serum levels are lower in men compared with women.2,3Nordeoxycholic acid has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS.4,5 1.Nakatomi, F., Kihira, K., Kuramoto, T., et al.Intestinal absorption and metabolism of norcholic acid in ratsJ. Pharmacobiodyn8(7)557-563(1985) 2.Tang, Y., Zhang, J., Li, J., et al.Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in ratsBiochim. Biophys. Acta Mol. Cell Biol. Lipids1864(10)1293-1304(2019) 3.Xie, G., Wang, Y., Wang, X., et al.Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MSJ. Proteome Res.14(2)850-859(2015) 4.Bergeron, A., Furtado, M., and Garofolo, F.Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assaysRapid Commun. Mass Spectrom.23(9)1287-1197(2009) 5.Evrard, E., and Janssen, G.Gas-liquid chromatographic determination of human fecal bile acidsJ. Lipid Res.9(2)226-236(1968) |
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