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Phenoxodiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenoxodiol图片
CAS NO:81267-65-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Phenoxodiol是一种合成genestein的类似物,激活线粒体caspase系统,抑制XIAP(一个凋亡抑制剂),使癌细胞对fas介导的凋亡敏感。Phenoxodiol还通过稳定可分裂复合物抑制DNA拓扑异构酶II,从而阻止DNA复制。Phenoxodiol 在细胞周期的G1/S期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1。
Cas No.81267-65-4
别名脱氢雌马酚,Idronoxil; Dehydroequol; Haginin E
Canonical SMILESOC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1
分子式C15H12O3
分子量240.25
溶解度DMSO: ≥ 100 mg/mL (416.23 mM); Water:< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Caspase, DNA topoisomerase II[1][2].

[1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.