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NG 52
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NG 52图片
CAS NO:212779-48-1
包装与价格:
包装价格(元)
Free Sample (0.1-0.5mg)电议
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
NG 52 (Compound 52 )是可渗透入细胞的,可逆的,非ATP竞争性的细胞周期调节激酶Cdc28p和Pho85p激酶抑制剂,IC50分别为7 μM和2 μM。
Cas No.212779-48-1
别名2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇,Compound 52
Canonical SMILESClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1
分子式C16H19ClN6O
分子量346.81
溶解度DMSO: 100 mg/mL (288.34 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM). cdc2-cyclin B|0.34 μM (IC50)|Pho85p|2 nM (IC50)

[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.