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CI 972(anhydrous)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CI 972(anhydrous)图片
CAS NO:115787-68-3
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CI 972 anhydrous 是一会有效的，具有口服活性的，竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM)，正在开发作为T细胞选择性免疫抑制剂。
Cas No.115787-68-3
Canonical SMILESO=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl
分子式C11H12ClN5OS
分子量297.76
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. Ki: 0.83 μM (PNP)[1]

CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].

[1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. [2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8.