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Cdc7-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cdc7-IN-1图片
CAS NO:1402055-25-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Cdc7-IN-1 (Compound 13) 是一种高效、选择性的 ATP 竞争性的 Cdc7 激酶抑制剂,在 1 mM ATP 存在时对 Cdc7 作用的 IC50 值为 0.6 nM,具有解离率低的特质。Cdc7-IN-1 能高效地抑制癌细胞中的 Cdc7,诱导细胞死亡。
Cas No.1402055-25-7
Canonical SMILESO=C1C(C(OCC)=O)=C(NC2=C(Cl)C=CC=C2)O/C1=C\C3=CNC4=C3C=CC=N4
分子式C21H16ClN3O4
分子量409.82
溶解度DMSO: 5.2 mg/mL (12.69 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1]. IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1]

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.