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Diflucortolone 21-valerate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diflucortolone 21-valerate图片
CAS NO:59198-70-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Diflucortolone 21-valerate 是一种强效皮质类固醇,局部用于研究各种皮肤病。
Cas No.59198-70-8
别名戊酸双氟可龙
Canonical SMILESF[C@@]12[C@](C[C@@H](C([C@@]2(C=C3)C)=CC3=O)F)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@H]([C@@H](C4)C)C(COC(CCCC)=O)=O)C
分子式C27H36F2O5
分子量478.6
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Diflucortolone 21-valerate is a glucocorticoid.1It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50= 9.7 µg/ml).2Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.3,1Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.

1.Igawa, K., Katayama, I., Minatohara, K., et al.Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivityAllergol. Int.46(1)33-41(1997) 2.Yamada, K., Hattori, S., Hakoda, T., et al.A fundamental study on a bioassay for the antiphlogistic effect of topically applied antiinflammatory agentsNihon Yakurigaku Zasshi75(8)789-798(1979) 3.Kimura, T., and Doi, K.Dorsal skin reactions of hairless dogs to topical treatment with corticosteroidsToxicol. Pathol.27(5)528-535(1999)