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Tenofovir-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenofovir-d6图片
CAS NO:1020719-94-1
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of tenofovir
Cas No.1020719-94-1
别名反式-替诺福韦-d6
Canonical SMILESOP(COC(C([2H])([2H])[2H])([2H])C([2H])([2H])N1C=NC2=C(N)N=CN=C21)(O)=O
分子式C9H8D6N5O4P
分子量293.3
溶解度DMSO: Sparingly,Water: Sparingly
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tenofovir-d6is intended for use as an internal standard for the quantification of tenofovir by GC- or LC-MS. Tenofovir is an analog of adenosine monophosphate that has antiviral activity.1,2It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.3,4Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.4Forin vivoand cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil (fumarate) , which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.

1.Balzarini, J., Vahlenkamp, T., Egberink, H., et al.Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI miceAntimicrobial Agents and Chemotherapy41(3)611-616(1997) 2.Balzarini, J., Holy, A., Jindrich, J., et al.Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurineAntimicrobial Agents and Chemotherapy37(2)332-338(1993) 3.Van Gelder, J., Shafiee, M., De Clercq, E., et al.Species-dependent and site-specific intestinal metabolism of ester prodrugsInternational Journal of Pharmacy205(1-2)93-100(2000) 4.Robbins, B.L., Srinivas, R.V., Kim, C., et al.Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPAAntimicrobial Agents and Chemotherapy42(3)612-617(1998)