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Rifampicin-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rifampicin-d3图片
CAS NO:1262052-36-7
包装:500 μg
市场价:3765元

产品介绍
An internal standard for the quantification of rifampicin
Cas No.1262052-36-7
别名利福平 d3
Canonical SMILESOC1=C2C(C(O)=C(C)C(O[C@]3(C)O/C=C/[C@H](OC)[C@H](C)[C@]([C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C(C)/C(N4)=O)(OC(C)=O)[H])=C2C3=O)=C(O)C4=C1/C=N/N5CCN(C([2H])([2H])[2H])CC5
分子式C43H55D3N4O12
分子量826
溶解度Chloroform: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rifampicin-d3is intended for use as an internal standard for the quantification of rifampicin by GC- or LC-MS. Rifampicin is a rifamycin antibiotic and inhibitor of bacterial RNA polymerase (IC50= 0.01 μg/ml for theE. colienzyme).1It inhibits the growth ofM. tuberculosisH37Rv in mouse peritoneal macrophages (MIC = 0.8 μg/ml) as well as clinical isolates of various species ofStaphylococcus,Streptococcus,Haemophilus, andNeisseria(MICs = 0.009-1.4 μg/ml).2,3Rifampicin increases survival in a mouse model of tuberculosis infection.3It is also an agonist of the human pregnane X receptor (PXR; EC50= ~2 μM).4Formulations containing rifampicin have been used in the treatment of tuberculosis and meningococcal carriers.

1.Wehrli, W.Rifampin: Mechanisms of action and resistanceRev.Infect.Dis.5(3)S407-S411(1983) 2.Jhamb, S.S., Goyal, A., and Singh, P.P.Determination of the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro: MGIT 960 as a viable alternative for BACTEC 460Braz. J. Infect. Dis.18(3)336-340(2014) 3.Arioli, V., Berti, M., Carniti, G., et al.Antibacterial activity of DL 473, a new semisynthetic rifamycin derivativeJ. Antibiot. (Tokyo)34(8)1026-1032(1981) 4.Gill, S.K., Xu, H., Kirchhoff, P.D., et al.Structure-based design of novel benzoxazinorifamycins with potent binding affinity to wild-type and rifampin-resistant mutant Mycobacterium tuberculosis RNA polymerasesJournal of Medicinal Chemistry55(8)3814-3826(2012)