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L-Valacyclovir-d8(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-Valacyclovir-d8(hydrochloride)图片
CAS NO:1279033-32-7
包装与价格：
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of valacyclovir
Cas No.1279033-32-7
别名盐酸伐昔洛韦 d8 (盐酸盐)
Canonical SMILESNC(NC1=C2N=CN1COCCOC([C@](N)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)=NC2=O.Cl
分子式C13H12D8N6O4.HCl
分子量368.8
溶解度DMF: 10 mg/ml,DMSO: 3 mg/ml,Ethanol: Insolule,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Valacyclovir-d8is intended for use as an internal standard for the quantification of L-valacyclovir by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir . L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50= 0.84 µM in Vero cells).1It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovirin vitro, however, it is rapidly converted to acyclovirin vivo.2Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.

1.Beauchamp, L.M., Orr, G.F., de Miranda, P., et al.Amino acid ester prodrugs of acyclovirAntivir. Chem. Chemother.3(3)157-164(1992) 2.Beutner, K.R.Valacyclovir: A review of its antiviral activity, pharmacokinetic properties, and clinical efficacyAntiviral Res.28(4)281-290(1995)