| CAS NO: | 1133378-37-6 |
| 包装: | 1mg |
| 市场价: | 6426元 |
| Cas No. | 1133378-37-6 |
| 别名 | 九氘代地瑞拉为,TMC114-d9; UIC-94017-d9 |
| Canonical SMILES | O=C(N[C@@H](CC1=CC=CC=C1)[C@@H](CN(C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])S(C2=CC=C(N)C=C2)(=O)=O)O)O[C@H]3CO[C@]4([H])[C@@]3([H])CCO4 |
| 分子式 | C27H28D9N3O7S |
| 分子量 | 556.7 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Darunavir-d9is intended for use as an internal standard for the quantification of darunavir by GC- or LC-MS. Darunavir is an HIV-1 protease inhibitor.1It is active against HIV-1LAIin MT-2 cells (IC50= 3 nM) with a cytotoxic concentration (CC50) of 74.4 μM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells (PHA-PBMCs; IC50s = 3 and 3-29 nM, respectively). It inhibits cell-free diffusion and cell-to-cell spread of HIV-1 in Jurkat cell populations (IC50s = 2.5 and 2.8 nM, respectively).2Formulations containing darunavir have been used in combination therapy for the treatment of HIV. 1.Koh, Y., Nakata, H., Maeda, K., et al.Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitroAntimicrob. Agents Chemother.47(10)3123-3129(2003) 2.Titanji, B.K., Aasa-Chapman, M., Pillay, D., et al.Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cellsRetrovirology10161(2013) |
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