CAS NO: | 8064-90-2 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
Cas No. | 8064-90-2 |
Canonical SMILES | COC1=C(OC)C(OC)=CC(CC2=CN=C(N)N=C2N)=C1.NC3=CC=C(S(NC4=NOC(C)=C4)(=O)=O)C=C3 |
分子式 | C14H18N4O3.C10H11N3O3S |
分子量 | 543.6 |
溶解度 | DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 0.3mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole and trimethoprim .1,2It is bactericidal against 12 patient-derived community-acquired methicillin-resistantS. aureus(MRSA) strains when used at a concentration of 0.05 mg/L.2Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaledB. malleiinfection, but does not eradicate infection when administered postB. malleiexposure in the same model.3It also resolves cutaneous tail lesions in a mouse model ofS. xylosusinfection.4Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively. 1.Lewis, E.L., Anderson, J.D., and Lacey, R.W.A reappraisal of the antibacterial action of cotrimoxazole in vitroJ. Clin. Pathol.27(2)87-91(1974) 2.Kaka, A.S., Rueda, A.M., Shelburne, S.A., III, et al.Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureusJ. Antimicrob. Chemother.58(3)680-683(2006) 3.Barnes, K.B., Steward, J., Thwaite, J.E., et al.Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glandersInt. J. Antimicrob. Agents41(6)552-557(2013) 4.Thornton, V.B., Davis, J.A., St. Clair, M.B., et al.Inoculation of Staphylococcus xylosus in SJL/J mice to determine pathogenicityContemp. Top. Lab. Anim. Sci.42(4)49-52(2003) |