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CAY10766
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10766图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An antiviral compound
Canonical SMILESFC(F)(F)C1=CC=C(C(NC2CCN(C(C)(C)C)CC2)=O)C(Cl)=C1
分子式C17H22ClF3N2O
分子量362.8
溶解度DMF: 11mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 10mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 µM). CAY10766 (1 µM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.

1.Gaisina, I.N., Peet, N.P., Cheng, H., et al.Optimization of 4?aminopiperidines as inhibitors of influenza A viral entry that are synergistic with oseltamivirJ. Med. Chem.63(6)312-3130(2020)