| CAS NO: | 163921-65-1 |
| 包装: | 1mg |
| 市场价: | 3402元 |
| Cas No. | 163921-65-1 |
| 别名 | 阿奇霉素 13C-d3 |
| Canonical SMILES | C[C@@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@H](O)[C@H]1C)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)[C@H]([C@](O)(C[C@H](CN1C([2H])([2H])[2H])C)C)O[C@@](O[C@H](C)C[C@@H]3N(C)C)([H])[C@@H]3O |
| 分子式 | C38H69D3N2O12 |
| 分子量 | 752 |
| 溶解度 | DMSO: 100 mg/ml,Ethanol: 100 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Azithromycin-d3is intended for use as an internal standard for the quantification of azithromycin by GC- or LC-MS. Azithromycin is a macrolide antibiotic.1It is active againstS. pneumoniae,S. aureus,N. gonorrhoeae,M. pneumoniae,H. pylori,C. trachomatis, andH. influenzae in vitro(MIC90s =<0.01-2 mg/L). Azithromycin increases survival in mouse models of intraperitonealS. pyogenes,S. pneumoniae,E. faecalis, orH. influenzaeinfection (ED50s = 0.78, 8.7, 12.7, and 30.3 mg/kg, respectively).2It also decreases plasma levels of IL-6, TNF-α, and IL-1β and increases survival in mouse model of LPS-induced sepsis when administered at a dose of 100 mg/kg.3Formulations containing azithromycin have been used in the treatment of a variety of bacterial infections. 1.Kanatani, M.S., and Guglielmo, B.J.The new macrolides. Azithromycin and clarithromycinWestern J. Med.160(1)31-37(1994) 2.Girard, D., Finegan, S.M., Dunne, M.W., et al.Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection modelsJ. Antimicrob. Chemother.56(2)365-371(2005) 3.Patel, A., Joseph, J., Periasamy, H., et al.Azithromycin in combination with ceftriaxone reduces systemic inflammation and provides survival benefit in a murine model of polymicrobial sepsisAntimicrob. Agents Chemother.62(9)e00752-00718(2018) |
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