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(S)-3'-amino Blebbistatin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-3'-amino Blebbistatin图片
CAS NO:2097141-18-7
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin, which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.
Cas No.2097141-18-7
Canonical SMILESO=C1[C@@]2(O)C(N(C3=CC=CC(N)=C3)CC2)=NC4=C1C=C(C)C=C4
分子式C18H17N3O2
分子量307.3
溶解度DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-amino group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-amino Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.