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TAN 1364B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAN 1364B图片
CAS NO:154639-24-4
包装与价格:
包装价格(元)
500μg电议
2.5mg电议

产品介绍
TAN 1364B 是 RK-682 的消旋体,是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。 TAN 1364B 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP) 和细胞分裂周期 25B (CDC-25B),IC50 为 8.6 μM, 12.4 μM 和 0.7 μM,分别。
Cas No.154639-24-4
Canonical SMILESO=C1C(C(CCCCCCCCCCCCCCC)=O)=C(O)C(CO)O1
分子式C21H36O5
分子量368.5
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.