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D-erythro-MAPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-erythro-MAPP图片
CAS NO:143492-38-0
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
D-erythro-MAPP (D-e-MAPP) 是一种神经酰胺酶抑制剂,在体外的 IC50 为 1-5 μM。
Cas No.143492-38-0
别名D-e-MAPP
Canonical SMILESO[C@H]([C@H](N(C(CCCCCCCCCCCCC)=O)[H])C)C1=CC=CC=C1
分子式C23H39NO2
分子量361.6
溶解度DMF: 20 mg/ml,DMSO: .1 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:2): .5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.