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PAK-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PAK-IN-1图片
CAS NO:1394121-05-1
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
PAK-IN-1 是一种 PAK 抑制剂,具有 II 组选择性。 PAK-IN-1 抑制 PAK4、PAK5 和 PAK6,IC50 分别为 7.5、36、126 nM。
Cas No.1394121-05-1
Canonical SMILESOC1(C#CC2=CC=C3N=C(NCCOC)N(C4=NC(N)=NC=C4)C3=C2)CCCCC1
分子式C22H26N6O2
分子量406.48
溶解度DMSO: 270 mg/mL (664.24 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PAK-IN-1 is a PAK inhibitor that displays group II selectivity. PAK-IN-1 inhibits PAK4, PAK5 and PAK6 with IC50s of 7.5, 36, 126 nM, respectively.

PAK-IN-1 is compound 4 from the reference[1].

[1]. Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.