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Novobiocin Sodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Novobiocin Sodium图片
CAS NO:1476-53-5
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Novobiocin (Albamycin) sodium 是一种有效且具有口服活性的抗生素。
Cas No.1476-53-5
别名新生霉素钠,Albamycin sodium; Cathomycin sodium
化学名sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
Canonical SMILESCC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
分子式C31H35N2O11.Na
分子量634.61
溶解度≥ 29.35mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Novobiocin Sodium is an antibiotic compound derived from Streptomyces niveus.Target: AntibacterialNovobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides a member of the order Actinobacteria . Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. The molecular basis of action of novobiocin, and other related drugs clorobiocin and coumermycin A1 has been examined. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. The potency of novobiocin is considerably higher than that of the fluoroquinolones that also target DNA gyrase, but at a different site on the enzyme. The GyrA subunit is involved in the DNA nicking and ligation activity [1-4].

References:
[1]. http://www.ncbi.nlm.nih.gov/pubmed/8231802
[2]. Maxwell, A., DNA gyrase as a drug target. Biochem Soc Trans, 1999. 27(2): p. 48-53.
[3]. Lewis, R.J., F.T. Tsai, and D.B. Wigley, Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays, 1996. 18(8): p. 661-71.
[4]. Maxwell, A. and D.M. Lawson, The ATP-binding site of type II topoisomerases as a target for antibacterial drugs. Curr Top Med Chem, 2003. 3(3): p. 283-303.