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Adenosine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Adenosine图片
CAS NO:58-61-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
500mg电议
1g电议
5g电议

产品介绍
腺苷(腺嘌呤核苷)是一种普遍存在的内源性 autacoid,通过四种 G 蛋白偶联受体 A1、A2A、A2B 和 A3 的登记发挥作用。
Cas No.58-61-7
别名腺苷; Adenine riboside; D-Adenosine
化学名(2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Canonical SMILESC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CO)O)O
分子式C10H13N5O4
分子量267.24
溶解度≥ 12.75mg/mL in DMSO with gentle warming
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.Target: Nucleoside antimetabolite/analogAdenosine plays an important role in biochemical processes, such as energy transfer — as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) — as well as in signal transduction as cyclic adenosine monophosphate, cAMP. It is also an inhibitory neurotransmitter, believed to play a role in promoting sleep and suppressing arousal. Adenosine also plays a role in regulation of blood flow to various organs through vasodilation.Adenosine is an endogenous purine nucleoside that modulates many physiological processes. Cellular signaling by adenosine occurs through four known adenosine receptor subtypes. Extracellular adenosine concentrations from normal cells are approximately 300 nM; however, in response to cellular damage (e.g. in inflammatory or ischemic tissue), these concentrations are quickly elevated (600–1,200 nM). Thus, in regard to stress or injury, the function of adenosine is primarily that of cytoprotection preventing tissue damage during instances of hypoxia, ischemia, and seizure activity. Activation of A2A receptors produces a constellation of responses that in general can be classified as anti-inflammatory.

References:
[1]. Sato A, et al. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1633-40.
[2]. Costa F, et al. Role of nitric oxide in adenosine-induced vasodilation in humans. Hypertension. 1998 May;31(5):1061-4.