您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > RITA(NSC 652287)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RITA(NSC 652287)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RITA(NSC 652287)图片
CAS NO:213261-59-7
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)292.4
FormulaC14H12O3S2
CAS No.213261-59-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 58 mg/mL (198.37 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 8 mg/mL (27.36 mM)
Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsNSC-652287; NSC652287; NSC 652287
实验参考方法
GeneralRITA is well tolerated in mice after intraperitoneal administration, with no observable weight loss at doses up to 10 mg/kg during 1 month. After five injections of 0.1 mg/kg of RITA, the growth of the HCT116 tumors is suppressed by 40%, without apparent effects on the HCT116 TP53-/- tumors. At a dose of 1 or 10 mg/kg, RITA shows strong antitumor activity.
Animal modelSCID mice carrying HCT116 and HCT116 TP53-/- xenografts
FormulationPhosphate buffered saline
Dosages0.1 mg/kg, 1 mg/kg or 10 mg/kg
Administrationi.p or i.v.
References[1] Issaeva N, et al. Nat Med. 2004, 10(12), 1321-1328.
生物活性